Studies have shown that fecal organisms can modify corticosteroids. The corticosteroids undergo reduction in ring A, and undergo side-chain dehydroxylation separately or sequentially with the reduction (48). Cortisol is converted to 21 -deoxycortisol, tetrahydrocortisol, and tetrahyro-21-deoxycortisol (48). Corticosterone is metabolized to tetrahydrocorticosterone, 21-deoxycorticosterone, and 3-alpha-hydroxy or 3-beta-hydroxy epimers of tetrahydro-21-deoxycorticosterone (48).
The intestinal bacteria can also transform progesterone similar to the reactions described above. Bacterial reduction of ring A can occur, as well as 16-alpha dehydroxylation, which can cause epimersation of the side chain (48).
Was this article helpful?
If Pregnancy Is Something That Frightens You, It's Time To Convert Your Fear Into Joy. Ready To Give Birth To A Child? Is The New Status Hitting Your State Of Mind? Are You Still Scared To Undergo All The Pain That Your Best Friend Underwent Just A Few Days Back? Not Convinced With The Answers Given By The Experts?