Other Steroid Hormone Bacterial Conversions

Studies have shown that fecal organisms can modify corticosteroids. The corticosteroids undergo reduction in ring A, and undergo side-chain dehydroxylation separately or sequentially with the reduction (48). Cortisol is converted to 21 -deoxycortisol, tetrahydrocortisol, and tetrahyro-21-deoxycortisol (48). Corticosterone is metabolized to tetrahydrocorticosterone, 21-deoxycorticosterone, and 3-alpha-hydroxy or 3-beta-hydroxy epimers of tetrahydro-21-deoxycorticosterone (48).

The intestinal bacteria can also transform progesterone similar to the reactions described above. Bacterial reduction of ring A can occur, as well as 16-alpha dehydroxylation, which can cause epimersation of the side chain (48).

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