Lincosamide

Clindamycin

The ecological impact of clindamycin on the fecal microbiota has been studied after intravenous clindamycin prophylaxis in patients undergoing colorectal surgery (78) and after oral administration in healthy subjects (79-81). Clindamycin is excreted in the bile and high fecal concentrations have been detected with marked disturbances, in particular in the anaerobic microbiota. Enterococci are not susceptible to clindamycin and their numbers have usually increased and so have the numbers of clindamycin-resistant enterobacteria. Anaerobic Gram-positive cocci and rods and anaerobic Gram-negative rods have been markedly suppressed or eliminated during treatment. Emergence of clindamycin-resistant Bacteroides species has been detected in one of the studies and colonization with C. difficile was common.

Pregnancy And Childbirth

Pregnancy And Childbirth

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