Info

<1-120

(110)

" Mean (Standard Deviation).

250 mgX2 for 7 days, 250 mg for 7 days and 125 mg for 21 days. c Initial dose 400 mg.

Abbreviations'. +, mild to moderate effect, increase or decrease 2^41ogl0 cfu/g feces; + +, strong impact >41ogl0 cfu/g feces; —, no significant changes; d, the detection limit; n.e., not examined.

" Mean (Standard Deviation).

250 mgX2 for 7 days, 250 mg for 7 days and 125 mg for 21 days. c Initial dose 400 mg.

Abbreviations'. +, mild to moderate effect, increase or decrease 2^41ogl0 cfu/g feces; + +, strong impact >41ogl0 cfu/g feces; —, no significant changes; d, the detection limit; n.e., not examined.

administration of tinidazole to healthy subjects, no significant changes have been detected in the gastrointestinal microbiota (89).

Metronidazole in Combination with Amoxycillin

In patients with Helicobacter pylori infection treated with omeprazole, metronidazole and amoxycillin, the alterations in the intestinal microbiota have been evaluated (90). Marked ecological disturbances were seen. The numbers of enterococci, enterobacteria, other than E. coli, and peptostreptococci increased significantly. Several patients became colonized with Klebsiella and Citrobacter species as well as with yeasts.

Metronidazole in Combination with Clarithromycin

The influence of H. pylori treatment with omeprazole, metronidazole and clarithromycin on the intestinal microbiota has been examined in two groups of patients (90,91). In the first mentioned study, it was found that the numbers of bifidobacteria, clostridia and species of Bacteroides were significantly decreased during treatment whereas the numbers of enterococci increased. Strains of enterococci, Enterobacteriaceae and Bacteroides spp. had significantly increased MIC values during the administration. In the second study the microbiota was compared to that of healthy subjects. Before treatment, patients were characterized by high concentrations of lactobacilli. Immediately after treatment there was an increased colonization with yeasts and enterobacteria, other than E. coli, while the growth of lactobacilli, clostridia and bacteroides decreased. Four weeks after the start of the study the microbiota of patients was similar to that in healthy subjects.

Pregnancy And Childbirth

Pregnancy And Childbirth

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