Conclusion

Despite the advanced techniques used in the simulators described here, they will remain only limited models of the authentic gastrointestinal tract. In particular, the interaction between the microbes and the host is absent including contact with the mucosa and the intestinal immune system. Some of these issues may be addressed by the use of intestinal cell lines, either in the simulator, as a separate loop in the simulator or by using simulator effluent. While the latter would remain approximations of the real situation, they would nevertheless be very valuable for providing further insight into the dynamics and activity of the gastrointestinal microbiota.

Pregnancy And Childbirth

Pregnancy And Childbirth

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