Gastrointestinal side effects

Gastrointestinal side effects are the most common side effects of almost all antiret-roviral drugs - nucleoside analogs, NNRTIs and particularly protease inhibitors -and occur especially during the early stages of therapy. Typical symptoms include abdominal discomfort, loss of appetite, diarrhea, nausea and vomiting. Heartburn, abdominal pain, meteorism and constipation may also occur. Nausea is a common symptom with zidovudine-containing regimens; diarrhea occurs frequently with zidovudine, didanosine and all PIs, particularly nelfinavir, as well as with saquinavir and lopinavir/r, atazanavir and ritonavir. Treatment with zidovudine rarely leads to a severe form of gastritic pain, nausea and vomiting in the early phase of therapy, in which case it should be discontinued.

In addition to the often considerable impact on everyday life, gastrointestinal side effects can lead to dehydration, malnutrition with weight loss, and low plasma drug levels with the risk of development of resistant viral strains. In most cases, symptoms occur at the beginning of therapy. Patients should be informed that these side effects usually resolve after four to six weeks of treatment. If gastrointestinal side effects occur for the first time after longer periods on HAART, other causes such as gastritis and infectious diarrhea are likely.

Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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