ART 20052006 The Horizon and Beyond

Christian Hoffmann, Fiona Mulcahy

Although more than two dozen different products are now available for treatment of HIV infection, there is a growing need for new drugs. This is not just true for patients with multiresistant viruses awaiting new treatment options. Significant problems related to long-term toxicity and adherence are anticipated with therapies that will presumably need to span whole decades, as eradication of HIV is currently not possible. As a result, there is an urgent need for new drugs that are easier to take, with high genetic barriers to the development of resistance and above all less toxic. To eventually reach the goal of eradication, new drugs need to be more potent than those available today. The following overview of substances that could make it to the clinic based on current data (December 2004) does not claim to be complete.

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