Vrisk Factors For

Besides duration of heparin administration, the three most important risk factors for HIT include: (1) type of heparin (UFH >> LMWH > fondaparinux); (2) type of patient (postsurgical > medical > obstetric/pediatric); and (3) patient gender (female > male) (Warkentin et al., 2005c, 2006) (see Chapter 3). Ironically, despite the greater risk of HIT in females (odds ratio, 1.5-2.0) (Warkentin et al., 2006), HIT is rare in pregnancy (Fausett et al., 2001), and has not been reported with LMWH administered during pregnancy (Greer and Nelson-Piercy, 2005).

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