S 30

Definite previous heparin exposure

| Rapid onset Q Typical onset of HIT of HIT

s100 days >100 days

Days since previous heparin treatment

FIGURE 2 Temporal patterns of HIT in 243 patients in relation to previous treatment with heparin. (A) Data are shown for the patients in whom the day of onset of HIT could be determined to within a 3-day period. Among 170 patients with typical onset of HIT, there was no significant difference in onset of HIT (median day), irrespective of whether previous heparin exposure had been definite (6.5, n = 47), possible (7.0, n = 49), or unlikely (6.0, n = 74) (p = 0.88, definite vs. unlikely). Among 120 patients who had definite previous exposure to heparin, 73 had rapid onset of HIT. (B) For the subgroup of patients with definite previous exposure to heparin, the 73 patients with rapid onset of HIT invariably had been exposed to heparin within the past 100 days (i.e., no patients shown at the asterisk [*]); in contrast, only 16/47 patients with typical onset of HIT had been exposed to heparin within the past 100 days (p < 0.001). Abbreviation: HIT, heparin-induced thrombocytopenia. Source: From Warkentin and Kelton, 2001a.

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