Nafamostat Mesilate

Nafamostat mesilate (FUT-175), a synthetic nonspecific serine protease inhibitor with a short half-life, has been evaluated for regional HD in patients at risk of bleeding (Akizawa et al., 1993). It has also been applied occasionally to HIT patients on HD (Koide et al., 1995). However, owing to significant clot formation at the dialyzer outlet, despite a 2-fold prolongation of aPTT, reported both in HIT and non-HIT patients (Koide et al., 1995; Matsuo et al., 1993; Takahashi et al., 2003), this anticoagulant cannot currently be recommended for HD of HIT patients.

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