Na

>50% fall

aResults of same RCT reported using two different definitions of thrombocytopenia (<150 and >50% fall), ineffective testing was used (platelet aggregation without heparin).

cOf seven patients with thrombocytopenia reported, two were excluded because of early onset of thrombocytopenia dThere is overlap in patients reported by Ganzer et al., 1997, 1999 and Greinacher et al., 2005a.

ePatients underwent laboratory testing for HIT antibodies if thrombosis developed even in the absence of thrombocytopenia. An additional 5 patients in Ganzer et al., 1997 developed thrombosis and positive HIPA test in absence of platelet count fall >50%, i.e., overall HIT frequency 20/307 = 6.5%.

Abbreviations: EIA, PF4-heparin enzyme-linked immunosorbent assay; HIPA, heparin-induced platelet activation test (aggregation of washed platelets); HIT, heparin-induced thrombocytopenia; ivther, intravenous therapeutic-dose heparin; LMWH, low molecular weight heparin; NA; not applicable; PRP, HIT assay using citrated platelet-rich plasma; sc proph, subcutaneous prophylactic-dose heparin; SRA, serotonin release assay using washed platelets; UFH, unfractionated heparin.

aResults of same RCT reported using two different definitions of thrombocytopenia (<150 and >50% fall), ineffective testing was used (platelet aggregation without heparin).

cOf seven patients with thrombocytopenia reported, two were excluded because of early onset of thrombocytopenia dThere is overlap in patients reported by Ganzer et al., 1997, 1999 and Greinacher et al., 2005a.

ePatients underwent laboratory testing for HIT antibodies if thrombosis developed even in the absence of thrombocytopenia. An additional 5 patients in Ganzer et al., 1997 developed thrombosis and positive HIPA test in absence of platelet count fall >50%, i.e., overall HIT frequency 20/307 = 6.5%.

Abbreviations: EIA, PF4-heparin enzyme-linked immunosorbent assay; HIPA, heparin-induced platelet activation test (aggregation of washed platelets); HIT, heparin-induced thrombocytopenia; ivther, intravenous therapeutic-dose heparin; LMWH, low molecular weight heparin; NA; not applicable; PRP, HIT assay using citrated platelet-rich plasma; sc proph, subcutaneous prophylactic-dose heparin; SRA, serotonin release assay using washed platelets; UFH, unfractionated heparin.

0 0

Post a comment