N Spontaneous HIT

On exceptionally rare occasions, patients spontaneously develop an illness that clinically resembles HIT, i.e., thrombocytopenia, thrombosis, and presence of platelet-activating anti-PF4/heparin (HIT) antibodies (Warkentin et al., 2006b). Typically there is a preceding inflammatory or surgical event. Sometimes, patients with antiphospholipid syndrome develop thrombocytopenia rapidly upon receiving heparin treatment, consistent with preexisting HIT antibodies associated with their autoimmune diathesis (Martinuzzo et al., 1999; Bourhim et al., 2003).

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