Management of the Patient with a Low or Intermediate Probability of HIT Pending Results of HIT Antibody Testing

Recommendation. In a patient with a low probability for HIT (e.g., 4T's score <3) pending the results of laboratory testing for HIT antibodies, we suggest either continuing the use of heparin or using alternative, non-heparin anticoagulation in prophylactic, rather than in therapeutic, doses (assuming there is no other reason for therapeutic-dose anticoagulation) (Grade 1C).

Recommendation. In a patient with an intermediate probability for HIT (e.g., 4T's score of 4 or 5), who has an alternative explanation for thrombocytopenia and who does not require therapeutic-dose anticoagulation for other reasons, we suggest alternative anticoagulation in prophylactic, rather than in therapeutic, doses (Grade 2C).

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