The Immune Response To Heparin

The finding that anti-PF4-heparin antibodies can be of the IgM, IgG, or IgA isotype (Visentin et al., 1994; Greinacher et al., 1994; Kelton et al., 1994; Amiral et al., 1995, 1996b; Arepally et al., 1997; Suh et al., 1997) indicates that class switching, likely requiring helper T cells, may occur in patients mounting a humoral immune response to PF4-heparin. Although HIT is a drug-induced disorder, parallels for the role of T cells in HIT may be drawn from studies of autoimmune

PF4 Tetramer (Front View)

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