FcyRIIa Activation In Hit

Although an association between heparin treatment and paradoxical thrombosis was first suspected about 40 yr ago (Weismann and Tobin, 1958; Roberts et al., 1964), it was Rhodes and colleagues (1973) who first provided evidence that serum from HIT patients contained a substance, most likely IgG, that aggregated normal platelets in the presence of heparin. This observation was confirmed by Fratantoni et al. (1975) who reported a simple indirect aggregation method for detecting HIT antibodies. In 1986, Sheridan and coworkers (1986) reported a washed platelet

PF4 - heparin - IgG complex

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