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748 UFH-treated patients admitted to a combined ICU and CCU over 2 yr. 267 had sufficient exposure to be considered at risk for HIT

145 consecutive patients admitted to a medical ICU with a normal platelet count

Stephan 147 consecutive et al., 1999 patients admitted to a surgical ICU over 6 mo period

Strauss et al., 2002

Thrombocytopenia was defined as a platelet count <150x 109/L; other clinical criteria for HIT not stated

>2 consecutive platelet counts <150x 109/L, or >33% drop, > 5 days after UFH exposure, or sooner if previously exposed within preceding 8 wk

Thrombocytopenia was defined as a platelet count <150x 109/L; other clinical criteria for HIT not stated

Thrombocytopenia was defined as a platelet count <100 x 109/l_; other criteria for HIT not stated

121/261 (46%) (62 patients were thrombocytopenic at admission; 59 developed thrombocytopenia during ICU admission) Not stated

Not stated

Not stated

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