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FIGURE 2 Cumulative frequency of thrombosis in patients presenting with isolated HIT (n = 62). Approximately 50% of HIT patients initially recognized with isolated HIT developed objective evidence for thrombosis during the subsequent 30-day period. The 1- and 2-day thrombotic event rates were approximately 10% and 18%, respectively. About 5% (3/62) patients developed sudden death as their presenting thrombotic event. Abbreviation: HIT, heparin-induced thrombocytopenia. Source: From Warkentin and Kelton, 1996.

10 12 14 16 18 20 22 24 26 28 30 > after recognition of thrombocytopenia

10 12 14 16 18 20 22 24 26 28 30 > after recognition of thrombocytopenia

FIGURE 2 Cumulative frequency of thrombosis in patients presenting with isolated HIT (n = 62). Approximately 50% of HIT patients initially recognized with isolated HIT developed objective evidence for thrombosis during the subsequent 30-day period. The 1- and 2-day thrombotic event rates were approximately 10% and 18%, respectively. About 5% (3/62) patients developed sudden death as their presenting thrombotic event. Abbreviation: HIT, heparin-induced thrombocytopenia. Source: From Warkentin and Kelton, 1996.

TABLE 6 Proportion of Patients with HIT Developing HIT-Associated Thrombosis in Prospective Studies Employing In Vitro Laboratory Testing or in Which Data on Timing of Platelet Count Fall Were Reported

Thrombotic

TABLE 6 Proportion of Patients with HIT Developing HIT-Associated Thrombosis in Prospective Studies Employing In Vitro Laboratory Testing or in Which Data on Timing of Platelet Count Fall Were Reported

Thrombotic

Study

Major indication for heparin

ln vitro test

Number treated

Definition of thrombocytopenia (x I09/L)

Patients with HIT (using more sensitive definition of HIT)

complication of HIT

Venous Arter

Medical patients (therapeutic dose heparin)

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