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Note: Venous thrombosis was documented by bilateral venography or by the occurrence of pulmonary embolism. Of the 222 patients enrolled in the study, 177 patients had technically adequate bilateral venography or clinically documented pulmonary embolism and were considered in the analysis of efficacy. Major bleeding was defined as a fall in hemoglobin level of >2 g/dL or transfusion of >2 units of blood. All other clinically overt bleeding was classified as minor.

aSignificantly lower overall DVT rate compared with the first four regimens combined: 8/46 (17%) vs. 56/131 (43%); p < 0.05.

bSignificantly lower proximal DVT rate compared with the first regimens combined: 1/46 (2%) vs. 26/131 (20%); p < 0.01.

Abbreviation: DVT, deep vein thrombosis. Source: Ginsberg et al., 1994b.

Note: Venous thrombosis was documented by bilateral venography or by the occurrence of pulmonary embolism. Of the 222 patients enrolled in the study, 177 patients had technically adequate bilateral venography or clinically documented pulmonary embolism and were considered in the analysis of efficacy. Major bleeding was defined as a fall in hemoglobin level of >2 g/dL or transfusion of >2 units of blood. All other clinically overt bleeding was classified as minor.

aSignificantly lower overall DVT rate compared with the first four regimens combined: 8/46 (17%) vs. 56/131 (43%); p < 0.05.

bSignificantly lower proximal DVT rate compared with the first regimens combined: 1/46 (2%) vs. 26/131 (20%); p < 0.01.

Abbreviation: DVT, deep vein thrombosis. Source: Ginsberg et al., 1994b.

times a day). Proximal DVT occurred in only 2% of patients in the highest-dose regimen. Bleeding rates were low (<5%) with all regimens.

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