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recently reported effects on inflammation (decreased concentration of high sensitivity C-reactive protein seen 30 days after PCI), thrombin generation and activity (Keating et al., 2005a), decreased platelet reactivity and platelet-leukocyte aggregates, and leukocyte activation (Keating et al., 2005b) may make it more useful than heparin in the platelet-rich environment of active coronary lesions, where platelet activation and thrombin formation both play significant roles.

The anticoagulant effects of bivalirudin reverse rapidly, with coagulation times returning to baseline within 1-2 h after stopping the infusion (Fox et al., 1993).

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