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(Innohep® ) p-elimination aRatio of anti-Xa activity (lU/mg) to anti-IIa activity (lU/mg).

bBemiparin is the first example of the second-generation LMWHs, which are defined to have mean MW<4.0 kDa, a proportion of fragments > 6.0 kDa < 15%, and an anti-Xa:anti-IIa ratio > 4:1. cFrom Monographs in European Pharmacopoeia, 5th ed. Abbreviations: INN, International Nonproprietary Name; MW, molecular weight.

(Innohep® ) p-elimination aRatio of anti-Xa activity (lU/mg) to anti-IIa activity (lU/mg).

bBemiparin is the first example of the second-generation LMWHs, which are defined to have mean MW<4.0 kDa, a proportion of fragments > 6.0 kDa < 15%, and an anti-Xa:anti-IIa ratio > 4:1. cFrom Monographs in European Pharmacopoeia, 5th ed. Abbreviations: INN, International Nonproprietary Name; MW, molecular weight.

with females having a higher risk of HIT than males, especially with UFH treatment (Warkentin et al., 2006b).

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