Back pain

916 (42%)

944 (44%)


330 (15%)

358 (17%)


264 (12%)

225 (10%)

Injection site pain

174 (8%)

274 (13%)


142 (7%)

139 (6%)

Pelvic pain

130 (6%)

169 (8%)


127 (6%)

140 (7%)

Abdominal pain

103 (5%)

104 (5%)


103 (5%)

108 (5%)


102 (5%)

87 (4%)

and in one study involving humans. In a rat model of venous thrombosis using injections of tissue thromboplastin combined with stasis, the administration of bivalirudin demonstrated a dose-dependent interruption of thrombus formation (Maraganore et al., 1991).

Ginsberg et al. (1994a) studied iv and sc injections of bivalirudin in 10 patients with calf-vein thrombosis to determine if single injections could inhibit thrombin generation in a sustained fashion. Prothrombin fragment (F1+2) levels were used as an index of thrombin generation. Significant reductions in F1+2 levels were noted at 6 h postinfection, but by 24 h, levels had increased significantly. These workers speculated that higher doses, more frequent sc injections, or prolonged infusions were required to achieve ongoing inhibition.

Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

Get My Free Ebook

Post a comment