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Because of its high charge density as well as the high linear flexibility conferred by its constituent L-iduronic acid residues, heparin also binds to a variety of plasma proteins, which theoretically could compete with platelets for heparin (Casu et al., 1988; Young et al., 1994). However, heparin binding to only two plasma proteins, antithrombin and fibronectin, interferes with heparin-induced platelet activation (Salzman et al., 1980; Chong and Ismail, 1989) or with binding of heparin to platelets (Horne and Chao, 1990).

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