PTCAa (CrCl < 30 mL/min)

Same as above


PTCAa (dialysis-dependent)

Same as above

0.25 mg/kg/hd


aAngiomax is indicated for patients with or at risk of HIT/HITTS undergoing PCI (non-HIT indications for bivalirudin are not listed here).

bThe post-bolus IV infusion is usually continued for the duration of the procedure; continuation of the infusion at this dose for up to 4 hours after the procedure is optional, at the discretion of the physician; after completing the 4-h infusion, additional bivalirudin may be given at a rate of 0.20 mg/kg/h for up to 20 h.

"According to the U.S. package insert, a reduction in the infusion dose should be considered if the CrCl is less than 30 mL/min.

dAccording to the U.S. package insert, if a patient is on hemodialysis, the infusion dose should be reduced to 0.25 mg/kg/h.

Abbreviations: CrCl, creatinine clearance; HIT, heparin-induced thrombocytopenia; HITTS, heparin-induced thrombocytopenia/thrombosis syndrome; PTCA, percutaneous transluminal coronary angioplasty.

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