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aFor PCI, consider reduction in bivalirudin infusion rate to 1.0 mg/kg/h (initial bolus unchanged). bFor PCI, reduce bivalirudin infusion rate to 0.25 mg/kg/h (initial bolus unchanged). Source: Robson, 2000; Robson et al., 2002; and The Medicines Company, 2005.

PTCA, the current package insert states that no dose reduction in the bolus is required, and that only in those individuals with a creatinine clearance <30 mL/ min or on hemodialysis should a reduction in the infusion dose be considered (The Medicines Company, 2005) (Table 1).

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