Drug target

Free Xa

Free and tissue-bound Xa

Abbreviation: AT, antithrombin.

Abbreviation: AT, antithrombin.

advantage of direct factor Xa inhibitors over the indirect inhibitors, because prothrombinase-bound factor Xa that is not inhibited can continue to generate thrombin and thereby promote thrombus formation. Because of the pharmacological differences between direct and indirect factor Xa inhibitors, it cannot be assumed that direct factor Xa inhibitors will achieve the same success as indirect factor Xa inhibitors such as fondaparinux.

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