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Time period relative to lepirudin therapy

FIGURE 4 Average rate of new thromboembolic complications per day in the HAT-1,-2, -3 studies (n = 381 patients). The bar width indicates the mean duration of the observation period (days) and is shown for three time periods: before, during, and after lepirudin therapy. The high average event rate (0.051 [5.1%] event per day during a mean period of 1.3 days) from diagnosis of HIT until start of lepirudin therapy indicates that cessation of heparin alone is insufficient to prevent HIT-associated thrombosis, thus warranting treatment with an alternative anticoagulant if HIT is strongly suspected. Abbreviations: HAT, heparin-associated thrombocytopenia; HIT, heparin-induced thrombocytopenia. Source: From Lubenow et al., 2005.

(5.5% vs. 8.0%; p = 0.44) and death (11.9% vs. 12.0%; p = 0.98) did not differ between the lepirudin group and the historical controls (Table 5).

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