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Nadir Platelet Counts(x10-9/L)Shownon aLog10 Scale

FIGURE 6 Platelet count nadirs and clinical profile of classic drug-induced immune-mediated thrombocytopenia versus serologically confirmed HIT. "Classic" drug-induced immune-mediated thrombocytopenia (e.g., caused by quinine, vancomycin, or glycoprotein IIb/IIIa antagonists, among other drugs) typically produces severe thrombocytopenia (median platelet count nadir, approximately 10 x 109/L) and associated mucocutaneous bleeding. In contrast, HIT typically results in mild-to-moderate thrombocytopenia (median platelet count nadir, about 60 x 109/L) and associated venous or arterial thrombosis. Note that the relative heights of the two peaks are not drawn to scale, as HIT is much more common than all other causes of drug-induced immune-mediated thrombocytopenia combined. Source: From Warkentin, 2007.

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