Pregnant or Nursing Women

Argatroban anticoagulation in pregnant or nursing women has not been studied. Teratology studies in rats reveal no evidence of impaired fertility or fetal harm due to argatroban (Argatroban Prescribing Information, U.S., 2002). Because animal reproductive studies are not always predictive of human response, it is recommended that the drug be used during pregnancy only if clearly needed. The successful use of argatroban therapy for 21 days during the second trimester of pregnancy in a woman with HIT and thrombosis has been described (Francis, 2004).

Argatroban is detected in rat milk (Iida et al., 1986). It is unknown whether argatroban is excreted in human milk, although many drugs are. Hence, it is recommended that a decision be made either to discontinue nursing or discontinue the drug.

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