Patients with a History of HIT Requiring Acute Anticoagulation

A subgroup analysis of the prospective studies of argatroban in HIT identified 36 patients with a history of serologically confirmed HIT who had fully recovered from their initial episode of HIT, had a normal platelet count, and had no exposure to heparin or other parenteral anticoagulants (except argatroban) during their hospitalization (Matthai et al., 2005). Each patient required acute anticoagulation, most often for venous thromboembolism or acute coronary syndrome, and 12 had previously received argatroban. All evaluable patients were successfully anticoagulated. No one had a major bleeding or a new thromboembolic event. There were no adverse events related to reexposure.

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