Lepirudin in Children

Although rare in children, HIT is important in the differential diagnosis of thrombocytopenia or unexplained thrombosis in the presence of heparin administration (Ranze et al., 1999; Klenner et al., 2004). Because of the rarity of HIT and its clinical heterogeneity in pediatric patients, it is difficult to design a standardized dosage protocol for lepirudin. Accordingly, current therapeutic recommendations are based on anecdotal experience. Given that children usually have normal renal function, the short half-life of lepirudin presents an advantage in the event of bleeding complications or the need for invasive procedures. However, the dose required may range between 0.05 and 0.22 mg/kg/h, depending on comorbidity and renal function (Schiffmann et al., 1997; Deitcher et al., 2002; Nguyen et al., 2003) (see Chapter 20).

0 0

Post a comment