Role of DTIs in the Treatment of HIT

Oral DTIs have not been evaluated for the treatment of HIT but share the potential of the parenteral DTIs for this indication. Parenteral DTIs are widely used for the management of HIT, particularly in the United States where danaparoid is not available. The availability of an oral DTI alternative to warfarin may reduce the potential for HIT-associated microthrombosis, as has been reported during warfarin administration during the acute or subacute phase of HIT (see Chapters 2 and 12).

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