Cd

Abbreviations-. CCRT, continuous renal replacement therapy; CCU, coronary care unit; CT, computed axial tomography; EIA, enzyme immunoassay; HIT, heparin-induced thrombocytopenia; ICU, intensive care unit; LMWH, low molecular weight heparin; NA, not applicable; PAT, platelet aggregation test; SRA, serotonin release assay; UFH, unfractionated heparin.

TABLE 5 Factors Influencing the Risk of HIT: Type of Heparin, Type of Patient Population, and Gender (Fixed-Effects Statistical Analysis)

Group

(number of studies)

95% CI Common OR

Common OR for HIT

Lower

Upper p-value

Overall effect of heparin type: UFH vs. LMWH (7) Overall effect of patient type: surgical vs. medical (7)a Overall effect of gender:

female vs. male (7) Studies of interactions of gender (females, males), patient type (surgical, medical), or both (female/surgical; female/ medical) on risk of HIT for UFH vs. LMWHb Female (7) Male (7)a

Comparison of the treatment effect of heparin type in females vs. the treatment effect in males, p = 0.0199 Surgical (4) Medical (3) Comparison of the treatment effect of heparin type in surgical vs. the treatment effect in medical patients, p = 0.0054 Female/surgical (4) Female/medical (3) Comparison of the treatment effect of heparin type in female surgical patients vs. the treatment effect in female medical patients, p = 0.1028

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