Platelet FcyRIIa Numbers

Variable expression of FcyRIIa numbers among individuals could affect susceptibility to immune complex diseases (Rosenfeld et al., 1987) or even to HIT. The number of platelet surface-expressed FcyRIIa molecules is increased dramatically in HIT (Chong et al., 1993b). However, increased FcyRIIa expression is also seen after in vitro activation of platelets by HIT antibodies. Elevated FcyRIIa numbers may be a consequence of platelet activation in HIT, rather than a proximate cause. This notion is supported by the fact that increased platelet FcyRIIa levels are seen in patients with atherothrombosis and diabetes mellitus (Calverley et al., 2002).

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