Laboratory Studies of Fondaparinux in HIT

Shortly after the identification of PF4/heparin as the major antigen in HIT (see Chapters 5-7), various structural determinants for antigen formation were clarified by Greinacher and colleagues (1994, 1995). Among these, increasing polysaccharide molecular weight and degree of sulfation increased the ability to form antigens with PF4 that were recognized by HIT antibodies.

In addition, several studies described a lack of in vitro cross-reactivity when HIT antibodies were tested in the presence of fondaparinux. Elalamy et al. (1995) examined the ability of plasma (or purified IgG) from 25 patients with documented HIT to induce aggregation of platelets from healthy volunteers in the presence of

TABLE 3 Clinical Studies of Fondaparinux in the Treatment of HIT-Associated Thrombosis

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TABLE 3 Clinical Studies of Fondaparinux in the Treatment of HIT-Associated Thrombosis

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