Angiographic Appearance

Lindsey and colleagues (1979) reported a distinct angiographic appearance of heparin-induced thromboembolic lesions, described as "broad-based, isolated, gently lobulated excrescences which produced 30-95% narrowing of the arterial lumen. The abrupt appearance of such prominent luminal contour deformities in arterial segments that were otherwise smooth and undistorted was unexpected and impressive____ In each case, the lesions were located proximal to sites of arterial occlusion." The radiologic and surgical experience described suggests that distal embolization of "white" clots composed of "platelet-fibrin aggregates" accounted for the limb ischemia.

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