Chemical Description

Argatroban is a synthetic DTI derived from L-arginine (Fig. 1) (Okamoto and Hijikata, 1981; Kikumoto et al., 1984). Argatroban (molecular weight, 526.66) consists of a mixture of 2l-(R) and 2l-(S) stereoisomers in a ratio of approximately 65:35 (Rawson et al., 1993), with no interconversion between stereoisomers.

FIGURE 1 Chemical structure of argatroban. Its chemical name is 1-[5-[(ammoimino methyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]-pentyl]-4-methyl-2-piperidinecarboxylic acid, monohydrate, and its molecular weight is 526.66.

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