Diabetic Ketoacidosis

Diabetic ketoacidosis (DKA) can be associated with acute thromboembolic complications. In vitro studies indicate that high glucose levels enhance platelet activation by adenosine diphosphate (ADP) and other platelet agonists (Sudic et al., 2006). Evidence for in vivo platelet activation was observed in one study of 10 patients who had elevated plasma levels of platelet factor 4 (PF4) and b-thromboglobulin during DKA that resolved following recovery (Campbell et al., 1985). Evidence for...