In this chapter an attempt has been made to provide an overview of main image standardization functions, their implementation in clinical PACS, and applications to clinical diagnosis. Integration of standardization functions as an application package in clinical PACS adds a new quality to

TABLE 1 Comparison of standardization performed on acquisition and archive gateways Standardization on acquisition gateway Standardization on archive gateway

Standardized images are archived Rough images are archived

Standardization is performed once Standardization is performed many times

Does not affect the response time Slows down the system response time

Irreversible image damage in case of failure In case of failure, rough image is at the archive station the image diagnosis and image preview during seminars, conferences, and teaching. It improves the visual image perception, leading to a more accurate diagnosis, and it provides a shorter system response time. During the development of computer-aided diagnosis systems, the use of preprocessing and standardization of the image content permits efforts to be focused on new image processing procedures that lead to extraction of features, evaluation of their discriminant power, and eventually pattern recognition and image classification.

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