Construction of Multidimensional Brain Atlases

Arthur W. Toga 1 Introduction 635

Paul M. Thompson 2 Structure of a Brain Atlas 636

UCLA School of Medicine 2.1 Brain Templates

3 Types of Atlases 636

3.1 MRI • 3.2 Multimodality Atlases • 3.3 3D Anatomical Models

4 Coordinate Systems 637

5 Registration 639

6 Deformable Brain Atlases 640

6.1 Anatomic Variability

7 Warping 640

7.1 Model-Driven Registration • 7.2 Measuring Structural Differences

8 Multiple Modalities and Dimensions 643

9 Atlases of Cortical Patterns 644

9.1 Warping the Cerebral Cortex

10 Disease States 644

10.1 Genotype vs Phenotype

11 Dynamic Brain Atlases 646

11.1 4D Coordinate Systems • 11.2 Temporal Maps of Brain Structure

12 Conclusion 647

References 648

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