d3 d3

Me Me Me Me Ri Ri

31 32 33

Scheme 6.1.9. Synthesis of a benzodiazepine library using a silyl linker.

aryl halide. Because the silyl arene can be cleaved in the unwanted direction to give silylated arenes, further improvement led to the development of a germanium linker [40]; this gives rise to the formation of pure material. In addition, cleavage of these linkers can be accomplished by electrophiles, for example iodine, bromine, and chlorine, to yield halogenated residues thus converting this linker into a multiple cleavage linker system [41].

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