Pna

R1 I

R1 I

spatially addressable library

Scheme 6.2.2. Split-pool synthesis of PNA-encoded combinatorial libraries. R" = element of diversity present in library, B = base of the peptidonucleic acid, x = number of bases encoding a single element of diversity, n = number of chemical diversity-introducing steps, PG = protecting group.

hybridization to an oligonucleotide microarray spatially addressable library

Scheme 6.2.2. Split-pool synthesis of PNA-encoded combinatorial libraries. R" = element of diversity present in library, B = base of the peptidonucleic acid, x = number of bases encoding a single element of diversity, n = number of chemical diversity-introducing steps, PG = protecting group.

library present as a mixture

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