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pyrophosphate AMP

Scheme 6.5.1. ATP hydrolysis provides the energy for energetically demanding steps in metabolism.

In the F1 part, a hexameric a3b3 protein complex, the three b-units are catalyti-cally active. In a three-step process, conformational changes of the active site induce the binding of ADP and phosphate inside a pocket of the enzyme, followed by formation of the triphosphate from these reactants and subsequent release of the new ATP molecule from the active site. The conformational changes necessary for passage through this three-step cycle are caused by a bent, rotating protein axle in

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