NO as an Antioxidant

Interestingly, it has been proposed that NO' also has a protective role and, under certain conditions, acts as an antioxidant. Indeed, it has been shown that NO' can terminate a common pathological manifestation of oxidant overload to biological membranes, the deleterious process of lipid peroxidation [27], by reacting very rapidly with fatty alkoxyl (RO') and peroxyl (ROO') radical intermediates which would otherwise propagate the membrane damage. In addition, NO' can inhibit ferrylMb-induced oxidative damage by reducing ferrylMb to metMb [28].

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