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Linker and Cleavage Strategies

Apart from simple monofunctional cleavage, a variety of different linker strategies has been developed in recent years. In particular, new concepts based on safety-catch linkers, cyclative cleavage strategies, and fragmentation reactions have been presented. Cleavage of linkers can be monofunctional or with functionalization of the linking site, whatever is desired [103] (Figure 6.1.8). In the latter, also known as the multifunctional cleavage strategy, the number of library compounds is multiplied by the number of building blocks or functional groups that can be incorporated during the cleavage step. An anchoring group capable of functionalization and traceless linking is, therefore, a versatile tool for enhancing diversity in a given system.

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'Safety catch' linkers:

Attached molecule

'Safety catch' linkers:

Cyclization-cleavage linkers:

Cyclization-cleavage linkers:

Fragmentation/ Cycloreversion-cleavage linkers:

Fragmentation/ Cycloreversion-cleavage linkers:

Cleavage

Monofunctional linkers:

Cleavage

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