R2 = Allyl

One synthesis of benzofurans is based on cyclofragmentation. An appropriately substituted sulfone is used as a nucleophile in intramolecular ring opening of an epoxide. The resulting molecule loses a sulfinate and formaldehyde. By immobilization of the sulfinate on a resin this sequence can be used for the cleavage of benzofurans from solid supports [112] (Scheme 6.1.31).

9-37% total

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