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DIC, HOBT, DMF, r.t., o/n; (b) Bu4N+F~-H2O, DMF, r.t., o/n; (c) MsCl, pyridine, CH2Cl2, r.t., o/n.

applicable as chemical synthesis, microbiological chemistry often proves to be very successful if a microorganism is found that performs a transformation of interest. Further refinement by optimization of incubation conditions and nutrition media, and mutation and selection approaches, frequently leads to highly effective syntheses. Second generation combinatorial chemistry, on the other hand, enables rapid synthesis of large numbers of high-quality compounds. Combination of microbiological and combinatorial chemistry is, therefore, a powerful strategy for generation of novel, interesting test compounds.

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