Because the three dimensional structure of proteins is important for their specific function, it is, crucial to find ways of understanding, analyzing, and describing the folding of protein structures. In the 1960s Ramachandran introduced a method for analyzing the structure of proteins, starting from the results obtained by X-ray analysis in the solid state . Today this method is also used for description of protein structures obtained by NMR in solution or by molecular modeling.
Ramachandran pointed out that the folding of a protein depends on the conformation adopted by the two central a-bonds of each amino acid and that this conformation can be described by using the dihedral angles F and
B.2 Conformational Analysis of Proteins: Ramachandran's Method | 45
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