Info

Conclusions

The rapid development of combinatorial screening methods has been accompanied by the development of ever more efficient high-throughput analysis technologies. These not only enable analysis of catalytic activity but also the determination of enantiomeric excess [2, 21]. Taking these developments together, research in this field can be expected to yield highly active and selective catalysts with structures that could have not been predicted by conventional means.

References

1 For reviews see: (a) S. Dahmen, S. Brase, Synthesis 2001, 1431-1449; (b) H. WennemeES, Comb. Chem. High Throughput Screening 2001, 4, 273285; (c) B. JanDeieiT, D. J. Schaefer, T. S. Powers, H. W. Turner, W. H. WeinBerG, Angew. Chem. 1999, 111, 2648-2689; Angew. Chem. Int. Ed.

1999, 38, 2494-2532; (d) R. H. CraBTree, Chem. Commun. 1999, 1611-1616; (e) K. D. Shimizu, M. L. Snapper, A. H. HoveyDa, Chem. Eur. J. 1998, 4, 1885-1889. 2 M. T. ReeTZ, Angew. Chem. 2001, 113, 292-320; Angew. Chem. Int. Ed. 2001, 40, 312-329.

4 (a) P. Cong, R. D. Doolen, Q. Fan, D. M. Giaquinta, S. Guan, E. W. McFarland, D. M. Poojary, K. Self, H. W. Turner, W. H. Weinberg, Angew. Chem. 1999, 111, 507-512; Angew. Chem. Int. Ed. 1999, 38, 483488; (b) M. Orschel, J. Klein, H.-W. Schmidt, W. F. Maier, Angew. Chem. 1999, 111, 2961-2965; Angew. Chem. Int. Ed. 1999, 38, 2791-2794.

5 T. Johann, A. Brenner, M. Schwickardi, O. Busch, F. Marlow, S. Schunk, F. SchUth, Angew. Chem. 2002, 114, 3096-3100; Angew. Chem. Int. Ed. 2002, 41, 2966-2968.

6 A. C. Cooper, L. H. McAlexander, D.-H. LEE, M. T. TORRES, R. H. Crabtree, J. Am. Chem. Soc. 1998,

120, 9971.

7 K. H. Shaughnessy, P. Kim, J. F. Hartwig, J. Am. Chem. Soc. 1999,

121, 2123.

8 O. Lavastre, J. P. Morken, Angew. Chem. 1999, 111, 3357-3359; Angew. Chem. Int. Ed. 1999, 38, 3163-3165.

9 F. C. Moates, M. Somani, J. Annamaiai, J. T. Richardson, D. Luss, R. C. Willson, Ind. Eng. Chem. Res. 1996, 35, 4801-4803.

W. F. Maier, Angew. Chem. 1998, 110, 2788-2792; Angew. Chem. Int. Ed. 1998, 37, 2644-2647.

KUhling, A. Holzwarth, Angew. Chem. 1998, 110, 2792-2795; Angew. Chem. Int. Ed. 1998, 37, 2647-2650.

12 M. T. Reetz, M. H. Becker, M. Liebl, A. FUrstner, Angew. Chem. 2000, 112, 1294-1298; Angew. Chem. Int. Ed.

2000, 39, 1236-1239.

13 S. J. Taylor, J. P. Morken, Science 1998, 280, 267-270.

14 A. Berkessel, D. A. HErault, Angew. Chem. 1999, 111, 99-102; Angew. Chem. Int. Ed. 1999, 38, 102-105.

15 A. Berkessel, R. Riedl, J. Comb. Chem. 2000, 2, 215-219.

16 (a) G. T. Copeland, S. J. Miller, J. Am. Chem. Soc. 1999, 121, 4306-4307; (b) E. R. Jarvo, C. A. Evans, G. T. Copeland, S. J. Miller, J. Org. Chem.

2001, 66, 5522-5527.

17 G. T. Copeiand, S. J. Miller, J. Am. Chem. Soc. 2001, 123, 6496-6502.

18 R. F. Harris, A. J. Nation, G. T. Copeland, S. J. Miller, J. Am. Chem. Soc. 2000, 122, 11270-11271.

19 M. MULLER, T. W. MATHERS, A. P. Davis, Angew. Chem. 2001, 111, 39293931; Angew. Chem. Int. Ed. 2001, 40, 3813-3815.

20 P. Krattiger, C. McCarthy, A. Pfaltz, H. Wennemers, Angew. Chem. 2003, 115, 1763-1766; Angew. Chem. Int. Ed. 2003, 42, 1722-1724.

21 For excellent reviews see Ref. [2] and M. G. Finn, Chirality 2002, 14, 534540.

Part 6

Methodology, Bioengineering and Bioinspired Assemblies

0 0

Post a comment