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Design Principles and Binding Motifs of Existing Receptors

Like lectins, which undergo few if any changes in their global conformation on binding to sugars, most of the receptors reported so far have a rather rigid structure that provides a more or less well preorganized binding site for the substrate. Because of the high density of hydroxy groups on carbohydrates it is not surprising that most receptors are designed to target these functions to achieve binding. Although there is a growing number of very effective receptors that use boronic acid functions to form boronate esters with two appropriately orientated hydroxy

CO2Et

CO2Et

EtO2C

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