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Boron Linkers

Boronates have been used in a variety of linker types either as linkers for diols [42] or as precursors for metal-mediated cleavage. A boronic acid ester, which contains an aryl iodide moiety attached by an appropriate tether, can act as an intramolecular arylation agent. A polymer-bound precursor furnished a macrocyclic constrained ¿-turn peptide mimic via biaryl coupling, leading to cleavage [43] (Scheme 6.1.10).

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Scheme 6.1.10. Intramolecular cleavage Suzuki coupling.

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Scheme 6.1.10. Intramolecular cleavage Suzuki coupling.

A set of modern linkers is based on sulfur, stannane and selenium chemistry. A reason for this popularity is obviously because these elements can be tailored favorably for use as fragile points of attachment.

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