primary amines (R1NH2), to give immobilized secondary amines 10, and a set of eight isocyanates (R2NCO), to generate a 5 x 8 matrix of 40 immobilized steroidal ureas 11. Cleavage of the products from the solid support [25], then aqueous workup, finally gave the desired compounds 12 (Scheme 3.3.3) [30].

In summary, microbiological chemistry provides a means of rapid and often selective modification of a complex structure in one step, thus furnishing compounds difficult to obtain by purely chemical means. While not being as broadly

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